The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F COVER PAGE

OMB APPROVAL
OMB Number: 3235-0006
Expires: July 31, 2015
Estimated average burden
hours per response: 23.8

Report for the Calendar Year or Quarter Ended: 06-30-2018
Check here if Amendment   Amendment Number:
This Amendment (Check only one.):   is a restatement.
  adds new holdings entries.
Institutional Investment Manager Filing this Report:
Name: PERCEPTIVE ADVISORS LLC
Address: 51 ASTOR PLACE, 10TH FLOOR
NEW YORK , NY10003
Form 13F File Number: 028-10438

The institutional investment manager filing this report and the person by whom it is signed hereby represent that the person signing the report is authorized to submit it, that all information contained herein is true, correct and complete, and that it is understood that all required items, statements, schedules, lists, and tables, are considered integral parts of this form.

Person Signing this Report on Behalf of Reporting Manager:
Name: Joseph Edelman
Title: Managing Member
Phone: 646.205.5342
Signature, Place, and Date of Signing:
/s/ Joseph Edelman New York , NY 08-14-2018
[Signature] [City, State] [Date]
Report Type (Check only one.):
X 13F HOLDINGS REPORT. (Check here if all holdings of this reporting manager are reported in this report.)
  13F NOTICE. (Check here if no holdings reported are in this report, and all holdings are reported by other reporting manager(s).)
  13F COMBINATION REPORT. (Check here if a portion of the holdings for this reporting manager are reported in this report and a portion are reported by other reporting manager(s).)
Form 13F Summary Page
Report Summary:
Number of Other Included Managers: 0
Form 13F Information Table Entry Total: 127
Form 13F Information Table Value Total: 3,816,174
(thousands)
List of Other Managers Reporting for this Manager:
[If there are no entries in this list, omit this section.]
Form 13F File Number Name

List of Other Included Managers:
Provide a numbered list of the name(s) and Form 13F file number(s) of all institutional investment managers with respect to which this report is filed, other than the manager filing this report.
[If there are no entries in this list, state “NONE” and omit the column headings and list entries.]
No. Form 13F File Number Name


SEC FORM 13F-HR

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL
OMB Number: 3235-0006
Expires: July 31, 2015
Estimated average burden
hours per response: 23.8

COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABEONA THERAPEUTICS INC W EXP 12/24/201 00289Y115 12,810 1,259,636 SH SOLE 1,259,636 0 0
ABEONA THERAPEUTICS INC COM 00289Y107 954 59,662 SH SOLE 59,662 0 0
ABIOMED INC COM 003654100 14,990 36,646 SH SOLE 36,646 0 0
ACASTI PHARMA INC CL A NEW 00430K402 117 206,677 SH SOLE 206,677 0 0
ACCELERON PHARMA INC COM 00434H108 74,149 1,528,205 SH SOLE 1,528,205 0 0
ACHILLION PHARMACEUTICALS INC COM 00448Q201 2,830 1,000,000 SH SOLE 1,000,000 0 0
ADAMAS PHARMACEUTICALS INC COM 00548A106 28,004 1,084,159 SH SOLE 1,084,159 0 0
ADAPTIMMUNE THERAPEUTICS PLC SPONDS ADR 00653A107 585 49,302 SH SOLE 49,302 0 0
ADMA BIOLOGICS INC COM 000899104 29,410 6,521,102 SH SOLE 6,521,102 0 0
ADVERUM BIOTECHNOLOGIES INC COM 00773U108 428 80,845 SH SOLE 80,845 0 0
AEGLEA BIOTHERAPEUTICS INC COM 00773J103 272 25,694 SH SOLE 25,694 0 0
AGILE THERAPEUTICS INC COM 00847L100 1,744 3,530,000 SH SOLE 3,530,000 0 0
AKEBIA THERAPEUTICS INC COM 00972D105 22,110 2,215,400 SH SOLE 2,215,400 0 0
ALBIREO PHARMA INC COM 01345P106 60,504 1,704,330 SH SOLE 1,704,330 0 0
ALDEYRA THERAPEUTICS INC COM 01438T106 24,529 3,085,458 SH SOLE 3,085,458 0 0
ALEXION PHARMACEUTICALS INC COM 015351109 57,537 463,450 SH SOLE 463,450 0 0
ALLENA PHARMACEUTICALS INC COM 018119107 3,258 250,000 SH SOLE 250,000 0 0
ALLIQUA BIOMEDICAL INC COM PAR 019621309 867 423,394 SH SOLE 423,394 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 181,902 1,846,911 SH SOLE 1,846,911 0 0
AMICUS THERAPEUTICS INC COM 03152W109 312,782 20,024,424 SH SOLE 20,024,424 0 0
ANI PHARMACEUTICALS INC NOTE 3.005 12/0 00182CAA1 8,458 7,500,000 PRN SOLE 7,500,000 0 0
ARENA PHARMACEUTICALS INC COM NEW 040047607 36,710 841,978 SH SOLE 841,978 0 0
ARGENX SE ADR ADR 04016X101 43,879 529,560 SH SOLE 529,560 0 0
ARRAY BIOPHARMA INC COM 04269X105 673 40,133 SH SOLE 40,133 0 0
ARROWHEAD PHARMACEUTICALS INC COM 04280A100 4,970 365,445 SH SOLE 365,445 0 0
ASCENDIS PHARMA A S SPONSORED ADR 04351P101 71,352 1,072,647 SH SOLE 1,072,647 0 0
ASSEMBLY BIOSCIENCES INC COM 045396108 5,909 150,695 SH SOLE 150,695 0 0
ATHENAHEALTH INC COM 04685W103 23,871 150,000 SH SOLE 150,000 0 0
ATHENEX INC COM 04685N103 3,545 190,000 SH SOLE 190,000 0 0
AUDENTES THERAPEUTICS INC COM 05070R104 25,234 660,406 SH SOLE 660,406 0 0
AVEO PHARMACEUTICALS INC COM 053588109 4,274 1,891,192 SH SOLE 1,891,192 0 0
AXOGEN INC COM 05463X106 8,291 165,000 SH SOLE 165,000 0 0
AZURRX BIOPHARMA INC COM 05502L105 730 227,272 SH SOLE 227,272 0 0
BEIGENE LTD SPONSORED ADR 07725L102 876 5,700 SH SOLE 5,700 0 0
BIOHAVEN PHARMACEUTICAL HOLDING CO L COM G11196105 108,429 2,743,647 SH SOLE 2,743,647 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 61,014 961,147 SH SOLE 961,147 0 0
CAPITAL SR LIVING CORP COM 140475104 1,069 100,173 SH SOLE 100,173 0 0
CAPRICOR THERAPEUTICS INC COM 14070B101 5 4,000 SH SOLE 4,000 0 0
CAREDX INC COM 14167L103 5,724 467,676 SH SOLE 467,676 0 0
CASI PHARMACEUTICALS INC COM 14757U109 360 43,682 SH SOLE 43,682 0 0
CHAMPIONS ONCOLOGY INC COM NEW 158990812 2,326 366,972 SH SOLE 366,972 0 0
CLEARSIDE BIOMEDICAL INC COM 185063104 7,599 707,581 SH SOLE 707,581 0 0
COLLEGIUM PHARMACEUTICAL INC COM 19459J104 577 24,213 SH SOLE 24,213 0 0
CORIUM INTERNATIONAL INC COM 21887L107 50,921 6,357,133 SH SOLE 6,357,133 0 0
CYMABAY THERAPEUTICS INC COM 23257D103 36,808 2,742,821 SH SOLE 2,742,821 0 0
CYTOMX THERAPEUTICS INC COM 23284F105 43,930 1,921,715 SH SOLE 1,921,715 0 0
DBV TECHNOLOGIES SA SHS SPONSORED AMERICAN DEPOSIT ADR 23306J101 40,667 2,108,198 SH SOLE 2,108,198 0 0
DOVA PHARMACEUTICALS INC COM 25985T102 93,525 3,125,851 SH SOLE 3,125,851 0 0
EIDOS THERAPEUTICS INC COM 28249H104 13,971 686,922 SH SOLE 686,922 0 0
EIGER BIOPHARMACEUTICALS INC COM 28249U105 1,923 157,679 SH SOLE 157,679 0 0
ELLOX PHARMACEUTICALS INC COM 29014R103 50 2,961 SH SOLE 2,961 0 0
ENDOCYTE INC COM 29269A102 26,519 1,921,700 SH SOLE 1,921,700 0 0
EVOLENT HEALTH INC CL A 30050B101 1,474 70,000 SH SOLE 70,000 0 0
FERRARI N.V. COM N3167Y103 837 6,200 SH SOLE 6,200 0 0
FIAT CHRYSLER AUTOMOBILES N. SHS N31738102 1,171 62,000 SH SOLE 62,000 0 0
FLEXION THERAPEUTICS INC COM 33938J106 7,962 307,989 SH SOLE 307,989 0 0
FOAMIX PHARMACEUTICALS LTD SHS M46135105 5,598 1,117,324 SH SOLE 1,117,324 0 0
G1 THERAPEUTICS INC COM 3621LQ109 611 14,055 SH SOLE 14,055 0 0
GALAPAGOS NV SPON ADR 36315X101 13,908 150,875 SH SOLE 150,875 0 0
GERON CORP COM 374163103 2,887 2,350,000 SH Put SOLE 2,350,000 0 0
GERON CORP COM 374163103 35 200,000 SH Call SOLE 200,000 0 0
GLOBAL BLOOD THERAPEUTICS IN COM 37890U108 218,266 4,828,910 SH SOLE 4,828,910 0 0
GTX INC DEL COM NEW 40052B207 22,988 1,501,501 SH SOLE 1,501,501 0 0
HISTOGENICS CORP COM 43358V109 5,508 2,203,277 SH SOLE 2,203,277 0 0
HUMANA INC COM 444859102 44,114 148,218 SH SOLE 148,218 0 0
HUTCHISON CHINA MEDITECH LTD SPONSORED ADR 44842L103 301 10,000 SH SOLE 10,000 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602 47,848 100,000 SH SOLE 100,000 0 0
INVACARE CORP COM 461203101 3,720 200,000 SH SOLE 200,000 0 0
INVITAE CORP COM 46185L103 14,855 2,021,100 SH SOLE 2,021,100 0 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100 74,908 5,852,202 SH SOLE 5,852,202 0 0
IRHYTHM TECHNOLOGIES INC COM 450056106 24,989 308,006 SH SOLE 308,006 0 0
KADMON HLDGS INC COM 48283N106 52,531 13,165,746 SH SOLE 13,165,746 0 0
KINIKSA PHARMACEUTICALS LTD COM G5269C101 1,928 111,111 SH SOLE 111,111 0 0
LA JOLLA PHARMACEUTICAL CO COM PAR $.0001 2 503459604 125,828 4,313,611 SH SOLE 4,313,611 0 0
LOXO ONCOLOGY INC COM 548862101 653 3,765 SH SOLE 3,765 0 0
MADRIGAL PHARMACEUTICALS INC COM 558868105 9,010 32,213 SH SOLE 32,213 0 0
MARINUS PHARMACEUTICALS INC COM 56854Q101 6,417 907,732 SH SOLE 907,732 0 0
MEIRAGTX HOLDINGS PLC COM G59665102 53,900 4,703,398 SH SOLE 4,703,398 0 0
MENLO THERAPEUTICS INC COM 586858102 10,079 1,241,287 SH SOLE 1,241,287 0 0
MERIT MED SYS INC COM 589889104 55,399 1,082,013 SH SOLE 1,082,013 0 0
MIRATI THERAPEUTICS INC COM 60468T105 35,160 713,191 SH SOLE 713,191 0 0
MOLECULAR TEMPLATES INC COM 608550109 3,787 724,133 SH SOLE 724,133 0 0
MOMENTA PHARMACEUTICALS INC COM 60877T100 501 24,489 SH SOLE 24,489 0 0
MOTUS GI HLDGS INC COM 62014P108 20,207 2,810,542 SH SOLE 2,810,542 0 0
MYOKARDIA INC COM 62857M105 54,078 1,089,169 SH SOLE 1,089,169 0 0
NEKTAR THERAPEUTICS COM 640268108 296 6,057 SH SOLE 6,057 0 0
NEPTUNE TECHNOLOGIES AND BIORESO COM 64077P108 20,379 8,574,015 SH SOLE 8,574,015 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 463,226 4,715,250 SH SOLE 4,715,250 0 0
NEURONETICS INC COM 64131A105 3,340 125,500 SH SOLE 125,500 0 0
NUVECTRA CORP COM 67075N108 3,274 159,466 SH SOLE 159,466 0 0
ODONATE THERAPEUTICS INC COM 676079106 3,312 150,000 SH SOLE 150,000 0 0
ONCOMED PHARMACEUTICALS COM 68234X102 6,054 2,620,897 SH SOLE 2,620,897 0 0
ONCOSEC MED INC COM 68234L207 69 50,000 SH SOLE 50,000 0 0
PERNIX THERAPEUTICS HLDGS IN DBVC 4.250% 4/0 71426VAK4 426 1,000,000 PRN SOLE 1,000,000 0 0
PROTEON THERAPEUTICS INC COM 74371L109 819 334,116 SH SOLE 334,116 0 0
PTC THERAPEUTICS INC COM 69366J200 653 19,367 SH SOLE 19,367 0 0
PUMA BIOTECHNOLOGY INC COM 74587V107 187 100,000 SH Call SOLE 100,000 0 0
PUMA BIOTECHNOLOGY INC COM 74587V107 27,480 464,579 SH SOLE 464,579 0 0
QUOTIENT LTD SHS G73268107 52,058 6,483,020 SH SOLE 6,483,020 0 0
REGENXBIO INC COM 75901B107 62,215 867,106 SH SOLE 867,106 0 0
RETROPHIN INC COM 761299106 57,387 3,212,871 SH SOLE 3,212,871 0 0
RHYTHM PHARMACEUTICALS INC COM 76243J105 25,029 800,686 SH SOLE 800,686 0 0
SANGAMO THERAPEUTICS INC COM 800677106 355 25,000 SH SOLE 25,000 0 0
SENSEONICS HLDGS INC COM 81727U105 473 115,000 SH SOLE 115,000 0 0
SIERRA ONCOLOGY INC COM 82640U107 13,320 4,500,000 SH SOLE 4,500,000 0 0
SOLID BIOSCIENCES INC COM 3422E1055 141,708 3,977,222 SH SOLE 3,977,222 0 0
STRONGBRIDGE BIOPHARMA PLC COM G85347105 1,650 275,000 SH SOLE 275,000 0 0
SYNLOGIC INC COM 87166L100 9,268 942,852 SH SOLE 942,852 0 0
TABULA RASA HEALTHCARE INC COM 873379101 936 14,663 SH SOLE 14,663 0 0
TELADOC INC COM 87918A105 11,320 195,000 SH SOLE 195,000 0 0
TESARO INC COM 881569107 4,447 100,000 SH SOLE 100,000 0 0
TG THERAPEUTICS INC COM 88322Q108 258 100,000 SH Put SOLE 100,000 0 0
TRANSLATE BIO INC COM 89374L104 6,325 500,000 SH SOLE 500,000 0 0
UNIQURE NV SHS N90064101 54,607 1,444,628 SH SOLE 1,444,628 0 0
VBI VACCINES INC COM NEW 91822J103 26,581 9,665,843 SH SOLE 9,665,843 0 0
VERICEL CORP COM 92346J108 264 27,211 SH SOLE 27,211 0 0
VERONA PHARMA PLC SPONSORED ADR 925050106 307 22,327 SH SOLE 22,327 0 0
VERRICA PHARMACEUTICALS INC COM 92511W108 67,287 3,410,412 SH SOLE 3,410,412 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 12,900 75,898 SH SOLE 75,898 0 0
VICAL INC COM NEW 925602203 1,314 1,142,858 SH SOLE 1,142,858 0 0
VIEWRAY INC COM 92672L107 519 75,000 SH SOLE 75,000 0 0
VITAL THERAPIES INC COM 92847R104 405 150,000 SH Put SOLE 150,000 0 0
WAVE LIFE SCIENCES LTD SHS Y95308105 10,817 282,798 SH SOLE 282,798 0 0
XENCOR INC COM 98401F105 39,530 1,068,095 SH SOLE 1,068,095 0 0
XERIS PHARMACEUTICALS INC COM 98422L107 8,541 450,000 SH SOLE 450,000 0 0
ZOGENIX INC COM 98978L204 175,489 3,970,357 SH SOLE 3,970,357 0 0
ZYMEWORKS INC COM 98985W102 15,920 1,123,890 SH SOLE 1,123,890 0 0